Migraine, Epilepsy; and Ajulemic Acid as Anti-inflammatory

[palmspringsbum]

Wednesday, November 29 2006 @ 01:13 PM EST


Migraine, Epilepsy; and Ajulemic Acid as Anti-inflammatory

IACM via BBSNews 2006-11-29 -- The levels of the endocannabinoid anandamide in the cerebrospinal fluid are lower in chronic migraine patients compared to healthy subjects. This may help to explain why THC may help in migraine.

(Source: Sarchielli P, et al. Neuropsychopharmacology. 2006 Nov 22; [Electronic publication ahead of print])

<span class=postbigbold>Epilepsy </span>

In an experimental study application of CB1 receptor antagonists to neurons involved in epilepsy caused the development of continuous epileptiform activity. The induction of this activity by CB1 receptor antagonists was reversible and could be overcome by maximal concentrations of CB1 agonists. Authors concluded that endocannabinoids play an important role in the prevention of epilepsy.

(Source: Deshpande et al. Neurosci Lett 2007;411(1):11-16.)

<span class=postbigbold>Ajulemic acid </span>

In earlier studies ajulemic acid (AJA), a synthetic derivative of THC-COOH was reported to have anti-inflammatory and analgesic properties without the side effects produced by THC. Researchers of the Virginia Commonwealth University investigated the pharmacology of ajulemic acid. They concluded that AJA, like THC, binds to the CB1 receptor and exhibits psychoactive and therapeutic effects at nearly equal doses in preclinical models, suggesting no advantages over THC.

(Source: Vann RE et al. J Pharmacol Exp Ther 2006 Nov 14; [Electronic publication ahead of print])


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