CAT-310, by Cannasat Therapeutics; ganja without the 'buzz'

Medical marijuana studies.

Moderator: administration

CAT-310, by Cannasat Therapeutics; ganja without the 'buzz'

Postby budman » Wed Dec 26, 2007 4:46 pm

The Toronto Starr wrote:<span class=postbigbold>Pharmaceutical high on its new pain drug; CAT-310, from Toronto's Cannasat Therapeutics, is medical marijuana sans 'buzz'</span>

Toronto Star - Dec. 24, 2007
<table class=posttable align=right width=300><tr><td class=postcell><img class=postimg width=300 src=bin/irwin_sara-lee.jpg></tr></td><tr><td class=postcell><span class=postbold>Cannasat CEO David Hill talks with patient Sara Lee Irwin about her progress. Irwin, diagnosed with cancer in her pelvis and hip at 32, has also become the firm’s director of public relations.</span></tr></td></table>

They've heard all the jokes, and then some.

No, Cheech and Chong aren't on the payroll. Neither is the Weed Man. They don't have free samples, or the munchies. And their office Christmas party wasn't any wilder than yours was.

But as a small pharmaceutical firm working on a medicinal product derived from the same plant that's, um, high on the radar for recreational purposes, some ribbing is to be expected.

Luckily they take it all in stride at Toronto-based Cannasat Therapeutics Inc., one of a handful of companies in the world that is researching and developing medicines derived from cannabis plants (yes, that would be marijuana).

Their aim is something a lot more serious to help people suffering with chronic and neuropathic pain, depression, anxiety and movement disorders using all the known benefits of cannabis - including being a pain reliever, a relaxant, an anti-nauseant and an appetite stimulant - minus the social stigma of smoking pot.

On top of that, their first product in testing, CAT-310, takes away the so-called "buzz" of marijuana that makes some terminally and chronically ill patients, particularly the elderly, uncomfortable and anxious. This medicine is aimed directly at the $4 billion neuropathic pain market that is mainly serviced by various opiates, anti-convulsants and anti-depressants.

Cannasat's pursuit is all perfectly legal and has the backing of Health Canada, including a narcotics licence, "and you have to be a pure-bred pharmaceutical company to get one," notes chief executive David Hill.

His mission since Cannasat was launched in 2004 is to educate investors about the benefits of what he refers to more scientifically as "cannabinoids," the naturally occuring molecules unique to the cannabis plant. The best known is THC (tetrahydrocannabinol).

The idea is to mimic smoked cannabis through the invention of a new drug delivery technology that can be absorbed on the tongue, like a thin wafer. It doesn't get digested by the stomach and processed by the liver before reaching the brain, so it's similar to inhaling cannabis.

There are other products on the market using THC, including capsules and an oral spray, but anything that lands in the stomach and is processed by the liver increases the high, he explains.

"What we're trying to do is we've created a sublingual tablet so it goes into the mouth, into the bloodstream and then into the brain. What's compelling is when you take oral THC, it's five times more psycho-active. When it goes through your stomach and metabolizes, it's getting you high.

"So it's losing its efficacy and it's making you more stoned. So we're trying to take clinically proven molecules and reducing the high," Hill says.

One of the pluses is that THC is known to be an effective treatment for neuropathic pain and nausea.

"Most people who are sick don't want to get high. And what doctors are reluctant to do is prescribe medications that get you high," such as opiates, which can also be toxic, make you nauseas and constipated.

"Cannabinoids are safe. They're virtually non-toxic. We all remember from high school that if we drank too much we got sick. But if you smoke too much pot the worst thing that would happen to you is you fell asleep. And when you woke up the next day you might have been a tad groggy, but really there's no hangover.

"We know from recreational data that when some people take (smoke) too much THC it can cause paranoia, it can cause anxiety. Some people love it to death. They think it's just wonderful. But for some people it causes anxiety," says Hill.

Opiates such as Oxycontin and codeine can help with pain relief but they've been proven to be highly addictive. THC is much less so, he says.

"The biggest problem with oral dosage forms of THC today, the spray and the capsule, is that THC is a very thick, oily substance.

"Our solution is we have a nano-encapsulation technology. It takes that oily substance and turns it into a powder, so that powder will now dissolve in the saliva," and you don't have to swallow it, he explains.

"We know this works. If we can create a more elegant delivery system, I think we have a very marketable pharmaceutical product," Hill says.

One person who is excited about the medicine's potential is Sara Lee Irwin, Cannasat's director of public relations. When she was 32 years old she was diagnosed with cancer in her pelvis and hip. Today at 50, she walks with a cane and still suffers from chronic pain.

She's taken every powerful painkiller out there from Percodan to Oxycontin but found she couldn't function normally in her daily life because of the high, the constipation and the lack of appetite. She's taken THC in oral capsules but she's never found it as effective as smoking herbal cannabis.

Because of her condition, Irwin is one of the 2,000 people in Canada legally allowed to purchase and use medical marijuana, which she smokes three or four times daily to ease her suffering.

"I've switched over completely. It moves the pain off-centre and I have a ravenous appetite," she notes.

When it comes to her company's mission "I feel really good about what we're doing, and I have a great interest in this," Irwin adds.

Recently Cannasat reached a milestone they hope will get them closer to their goal of bringing a safe and effective product to market.

Earlier this month Cannasat successfully completed Phase I clinical trials, the first key study in humans that now provides them with important safety and medical data to launch them on to further product development.

"It's an important first step for us. It keeps us on track to move CAT-310 to Phase II testing by the end of 2008," he says.

It's at that point that the big pharmaceutical companies take notice and could sign on as a partner to market and distribute the product. They're already in preliminary talks with some, he says. They estimate revenue potential of $500 million-plus.

"We're not doing this to be a little, wee company. We see huge potential here," Hill says.

Cannasat went public last year on the TSX Venture Exchange and continues to trade at or around its 52-week low of 17 cents a share. Its market captialization is about $14 million.

Companies getting into Phase II of clinical trials, as they will be next fall, are trading north of $100 million in market cap, he says.

"We have great potential to be a big company with institutional money and move the research along further," Hill notes, adding their next products will be aimed at treating mood disorders such as anxiety and depression, and with localized pain.

But what about the public perception about pot?

"Now that we've established ourselves as a pharmaceutical company, I don't see that stigma. It certainly hasn't held us back in Canada. We've had a lot of support from Health Canada," offers Hill.

"I think the only stigma we have is that the average person, when they hear about it, their first reaction is cannabis is somehow a back alley drug. And I'm trying to show that (opiates) are a back alley drug too.

"I'm not some closet pot smoker or anything. I got into this because the company approached me with a business opportunity and I wanted to do something that I could be really passionate about.

"I realized there's an enormous business opportunity here that could really help people."
User avatar
Posts: 232
Joined: Sun Jun 11, 2006 6:38 pm Releases a Special Report

Postby palmspringsbum » Thu Feb 28, 2008 11:34 pm

AllPennyStocks wrote:Monday, Feb. 25 2008 Releases a Special Report on the Biotech / Medical Sector

MISSISSAUGA, Ontario, Feb 25, 2008 (PrimeNewswire via COMTEX) -- Media, Inc. ( announces its latest article by Glenn Wilkins, an News Reporter, this one discusses the Biotech / Medical sector, as well as some small cap companies that are making inroads in this sector.

The companies mentioned in the report include Cannasat Therapeutics Inc. (TSX-V:CTH), Aethlon Medical, Inc. (OTCBB:AEMD) and Neuralstem, Inc. (AMEX:CUR).

Glenn Wilkins notes that an often overlooked but important and lucrative industry for investors is the Biotech/Medical sector. In this sector, the main focus is the well being of humans and animals. For companies, the payoffs can be huge if a large pharmaceutical company takes notice of them, or if their drug is approved by the FDA, Health Canada or any other countries governmental drug gatekeepers. Once a drug or medical technology is developed, pre-clinical trials are initialized. The companies then go through a series of trial phases, where the drug or medical technology is put to the test.

Toronto-based Cannasat Therapeutics Incorporated is taking on that risk, developing medicines derived from cannabis plants. That's right, marijuana. The company's flagship product, CAT-310, purports to take away the "buzz" of smoking pot that could otherwise produce anxiety in elderly patients. The company hopes for a piece of the $4-billion neuropathic pain market, normally the domain of the anti-convulsants and anti-depressant market.

Other exciting developments are due out of San Diego-based Aethlon Medical Incorporated. The company is a pioneer in developing medical devices to treat infectious diseases, which, last in November, filed with the U.S. Patent Office what it calls the Aethlon Hemopurifier(r), a device meant to separate and capture circulating viruses, viral proteins, and toxins in a patients body before the occurrence of cell and organ infection. The device allows the patients natural immunity to recover and wage an effective battle against viral infections.

Neuralstem, Inc., a company headquartered in Rockville, Maryland, also looks on the cusp of something special. The company develops technology to produce neural stem cells of the brain and spinal cord in commercial quantities.

The full version of this special report can be found at: ... 022408.asp

User avatar
Site Admin
Site Admin
Posts: 2769
Joined: Sun Jun 11, 2006 6:38 pm
Location: Santa Cruz, California

Return to science

Who is online

Users browsing this forum: No registered users and 2 guests